Comparative genomic hybridization by array to provide genome-wide screening of cytogenetic abnormalities in multiple myeloma patients, a Czech center experience

In this paper, we demonstrated the possibility of effective utilization of oligonucleotide-based aCGH as a robust clinical tool for genome-wide scanning and detailed analysis of unbalanced genetic aberrations in 91 MM patients in combination with fluorescence in situ hybridization (FISH) in detection of high risk chromosomal aberrations. Loss of TP53 gene, translocation t(4;14)(p16;q32), gain in 1q21 and non-hyperdiploidy (non-hyperdiploid) area are associated with adverse prognosis in MM, thus their evaluation with other lesions obtained via genomic profiling could lead to better classification and risk assesment for thr patients.