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题目:: Comparative genomic hybridization to study capsule switching between serogroup C and W of Neisseria meningitidis strains
ID:
状态:: 发布时间June 3, 2009 , 更新时间 May 2, 2014 , 提交时间 Nov. 18, 2008,
物种:: Neisseria meningitidis
摘要:: Changing antigenic structure such as capsule polysaccharide is a common strategy for bacterial pathogen to evade host immune system. In this regard, the recent emergence of an invasive W:2a:P1.7-2,4 ST-11 strain in New Zealand, which is an uncommon pathogenic serogroup, was investigated for its genetic origins. Molecular typing of 103 meningococcal isolates with similar serotyping characteristics was undertaken to determine genetic relationships. Results indicated that the W:2a:P1.7-2,4 strain had emerged via capsule switching from an existing group C strain (C:2a:P1.7 2,4). Neither of the upstream and downstream sites of recombination could be elucidate but sequence analysis demonstrated that at least 45 kb of DNA was involved in the recombination event. This included the entire capsule gene cluster. Genomic DNA isolated from serogroup C strains (n=4) and serogroup W strains (n=4) were compared using Pan-neisseria DNA microarray.
实验种类:: comparative genomic hybridization by array
样本量:: 9
实验设计:
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数据号:: E-MEXP-1910
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