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题目:: Transcription profiling of yeast strains BY4743, Gis1delta and Rim15delta grown in ethanol- or glucose-limiting media
ID:
状态:: 发布时间Dec. 1, 2007 , 更新时间 May 2, 2014 , 提交时间 June 12, 2007,
物种:: Saccharomyces cerevisiae
摘要:: Cell growth is controlled by nutrients and growth factors. How cells are regulated to enter stationary phase is still poorly understood. Previously we have identified 17 yeast genes whose expression is significantly up-regulated following starvation for different macro-nutrients. Here we demonstrate that activation of some of these genes is dependent on the Rim15 kinase and the Gis1 transcription factor. Phenotypic and microarray analyses reveal that Rim15p and Gis1p have both overlapping and distinct functions suggesting a non-linear relationship between the two. Subsequently we demonstrate that independent of Rim15p, TOR controls the limited proteolysis of Gis1p and regulates the binding of functional fragments to their target promoters. The limited proteolysis of Gis1p is executed by the proteasome to prevent its target genes from over activation. Thus, TOR regulates the function of the proteasome in response to nutrients so that gene expression is properly controlled, not only during active growth, but also in stationary phase.
实验种类:: transcription profiling by array
样本量:: 12
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数据号:: E-MEXP-1139
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