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题目:: Transcription profiling of human SEG1 esophageal cell line treated with OSU-HDAC42, time series
ID:
状态:: 发布时间April 5, 2008 , 更新时间 June 10, 2011 , 提交时间 Dec. 19, 2007,
物种:: Homo sapiens
摘要:: Title: In vitro and in vivo effects of the orally bioavailable phenylbutyrate-derived histone deacetylase inhibitor OSU-HDAC42 on gene expression in esophageal tissues and in esophageal adenocarcinoma cells; Histone deacetylases (HDACs) modulate nucleosomal packaging of DNA, thereby influencing gene transcription and multiple cancer-associated processes. Thus, we conducted microarray analysis at multiple time-points to assess the ability of OSU-HDAC42, the S enantiomer of the previously published compound HDAC-42, to modulate key acid-induced changes as well as to impact other genes altered as the normal esophageal epithelium progresses along the metaplasia-dysplasia-esophageal adenocarcinoma continuum. Experiment Overall Design: SEG-1 cells were pretreated for 24 hours with vehicle or OSU-HDAC42, pulsed with acidified media (pH 3.5; 20 mins at 37C), replenished with media or OSU-HDAC42, and harvested 3, 6 and 24 hours later. Global gene expression analysis was conducted using the human genome chip U133 2.0 Plus.
实验种类:: transcription profiling by array
样本量:: 6
实验设计:
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数据号:: E-GEOD-9974, GSE9974
数据状态:: 无法自动分析，您可以尝试手动分析数据。

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