| GeneLibs

题目:: Transcription profiling of mouse lens from wild-type and transgenic strain ectopically expressing Foxe3
ID:
状态:: 发布时间Oct. 20, 2008 , 更新时间 June 10, 2011 , 提交时间 Nov. 28, 2007,
物种:: Mus musculus
摘要:: The vertebrate ocular lens consists of two basic cell types: the lens fibers, highly specialized cells that make up the bulk of the lens and are the basis for its unique optical characteristics, and the epithelial cells that cover the anterior hemisphere and acts as a stem cell population for progenitors of new fibers. The forkhead transcription factor FoxE3 is essential for maintenance, proliferation and survival of the epithelial cells, and silencing of the FoxE3 gene coincides with the cell cycle arrest that marks initiation of fiber cell differentiation. Here we have used transgenic ectopic expression of murine Foxe3 in fiber cells to investigate the consequences of persistent Foxe3 expression during fiber differentiation. Microarray transcript profiling showed that ectopic Foxe3 caused a general increase in mRNAs which are normally enriched in epithelial cells, consistent with an epithelialization of the transgenic fibers. Experiment Overall Design: Whole lenses from P2 animals were dissected and genotyped. 12 lenses from each genotype were used for RNA extraction and hybridization to Affymetrix arrays. Total of 3 replicates/genotype.
实验种类:: transcription profiling by array
样本量:: 6
实验设计:
: 无设计数据
数据号:: E-GEOD-9711, GSE9711
数据状态:: 无法自动分析，您可以尝试手动分析数据。

实验库数据相关信息

DataTable pData

联系方式

微信公众号

实验库 数据相关信息

DataTable pData

联系方式

微信公众号

实验库数据相关信息