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题目:: Transcription profiling of rat lacrimal gland samples from normal, sham and operated animals
ID:
状态:: 发布时间Oct. 12, 2007 , 更新时间 March 27, 2012 , 提交时间 Nov. 26, 2003,
物种:: Rattus norvegicus
摘要:: Previous studies showed that loss of muscarinic parasympathetic input to the lacrimal gland (LG) leads to a dramatic reduction in tear secretion and profound changes to LG structure. In this study, we used DNA microarrays to examine the regulation of the gene expression of the genes for secretory function and organization of the LG. Long-Evans rats anesthetized with a mixture of ketamine/xylazine (80:10 mg/kg) underwent unilateral sectioning of the greater superficial petrosal nerve, the input to the pterygopalatine ganglion. After 7 days, tear secretion was measured, the animals were killed, and structural changes in the LG were examined by light microscopy. Total RNA from control and experimental LGs (n = 5) was used for DNA microarray analysis employing the U34A GeneChip. Control rat lacrimal gland samples representing a normal unoperated, a sham, and paired contralateral controls. Experimental LG samples representing paired and unpaired contralateral controls. Paired contralateral control LGs represent LG from the same animal, one side was operated and the other side unoperated.
实验种类:: transcription profiling by array
样本量:: 10
实验设计:
: 无设计数据
数据号:: E-GEOD-844, GSE844, GDS508
数据状态:: 无法自动分析，您可以尝试手动分析数据。

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