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题目:: Transcription profiling of human prostate cancer primary cell line vs metastasis cell line reveals Protein 4.1B suppresses prostate cancer progression and metastasis
ID:
状态:: 发布时间June 15, 2008 , 更新时间 March 27, 2012 , 提交时间 May 28, 2007,
物种:: Homo sapiens
摘要:: Protein 4.1B is a 4.1/ezrin/radixin/moesin (FERM) domain-containing protein whose expression is frequently lost in a variety of human tumors, including meningiomas, non-small-cell lung cancers and breast carcinomas. However, its potential tumor suppressive function under in vivo conditions remains to be validated. In a screen for genes involved with prostate cancer metastasis, we found that 4.1B expression is reduced in highly metastatic tumors. Downregulation of 4.1B increased the metastatic propensity of poorly metastatic cells in an orthotopic model of prostate cancer. Furthermore, 4.1B-deficient mice displayed increased susceptibility for developing aggressive, spontaneous prostate carcinomas. In both cases, enhanced tumor malignancy was associated with reduced apoptosis. As expression of Protein 4.1B is frequently downregulated in human clinical prostate cancer, as well as in a spectrum of other tumor types, these results suggest a more general role for Protein 4.1B as a negative regulator of cancer progression to metastatic disease. Experiment Overall Design: primary cell line vs metastasis cell line
实验种类:: transcription profiling by array
样本量:: 6
实验设计:
: 无设计数据
数据号:: E-GEOD-7930, GSE7930
数据状态:: 无法自动分析，您可以尝试手动分析数据。

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