| GeneLibs

题目:: Transcription profiling of human melanoma to develop a gene signature for aggression of melanoma metastases based on a xenograft mouse model
ID:
状态:: 发布时间June 15, 2008 , 更新时间 June 10, 2011 , 提交时间 May 28, 2007,
物种:: Homo sapiens
摘要:: Metastasis is the deadliest phase of cancer progression. Experimental models using immunodeficient mice have been used to gain insights into the mechanisms of metastasis. We report here the identification of a “metastasis aggressiveness gene expression signature” derived using human melanoma cells selected based on their metastatic potentials in a xenotransplant metastasis model. Comparison with expression data from human melanoma patients shows that this metastasis gene signature correlates with the aggressiveness of melanoma metastases in human patients. Many genes encoding secreted and membrane proteins are included in the signature, suggesting the importance of tumor-microenvironment interactions during metastasis. Experiment Overall Design: parental cell line vs xenograft model
实验种类:: transcription profiling by array
样本量:: 32
实验设计:
: 无设计数据
数据号:: E-GEOD-7929, GSE7929
数据状态:: 无法自动分析，您可以尝试手动分析数据。

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