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题目:: Transcription profiling of human breast tissue tumors vs. normal tissue
ID:
状态:: 发布时间June 16, 2008 , 更新时间 June 10, 2011 , 提交时间 May 25, 2007,
物种:: Homo sapiens
摘要:: bulk breast tumor RNA from patient; Abstract: Sporadic basal-like cancers (BLC) are a distinct class of human breast cancers that are phenotypically similar to BRCA1-associated cancers. Like BRCA1-deficient tumors, most BLC lack markers of a normal inactive X chromosome (Xi). Duplication of the active X chromosome and loss of Xi characterized almost half of BLC cases tested. Others contained biparental but nonheterochromatinized X chromosomes or gains of X chromosomal DNA. These abnormalities did not lead to a global increase in X chromosome transcription but were associated with overexpression of a small subset of X chromosomal genes. Other, equally aneuploid, but non-BLC rarely displayed these X chromosome abnormalities. These results suggest that X chromosome abnormalities contribute to the pathogenesis of BLC, both inherited and sporadic. total 62 sample incudes 43 tumor, 7 normal breast and 12 normal organelle Experiment Overall Design: compare expression of tumor to normal breast tissue
实验种类:: transcription profiling by array
样本量:: 62
实验设计:
: 无设计数据
数据号:: E-GEOD-7904, GSE7904
数据状态:: 无法自动分析，您可以尝试手动分析数据。

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