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题目:: The sigma factor E of Mycobacterium tuberculosis modulates the inflammatory response of human THP1 cells
ID:
状态:: 发布时间May 25, 2010 , 更新时间 May 2, 2014 , 提交时间 May 21, 2007,
物种:: Homo sapiens
摘要:: Mycobacterium tuberculosis (Mtb) is well adapted to survive in macrophages and usually subverts the bactericidal mechanisms of these professional phagocytes. The adaptation of Mtb to the intracellular life depends on its ability to regulate the expression of its genes. Among the most important bacterial transcription activators are the sigma factors that bind to the RNA polymerase and give it promotor specificity. Sigma factor E (SigE) controls the expression of genes that are essential for Mtb virulence. Analysis of the macrophage transcriptional response indicated that proteins encoded by the sigE regulon are involved in the modulation of the macrophage inflammatory response. We compared the global gene expression of THP1 macrophages infected with H37Rv and SigE to the gene expression profile of uninfected macrophages.
实验种类:: unknown experiment type
样本量:: 20
实验设计:
: 无设计数据
数据号:: E-GEOD-7870, GSE7870
数据状态:: 无法自动分析，您可以尝试手动分析数据。

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