| GeneLibs

题目:: Transcription profiling of mouse multiple brain regions for a MPTP model of Parkinsons disease
ID:
状态:: 发布时间Oct. 26, 2008 , 更新时间 June 10, 2011 , 提交时间 May 4, 2007,
物种:: Mus musculus
摘要:: In Parkinson’s disease (PD), the progressive loss of substantia nigra dopamine cells has been associated with their vulnerability to oxidative stress, inflammation, and mitochondrial dysfunction. To identify multiple gene transcription alterations that may potentially underlie early stages of related degenerative processes in brain, we used the subcrhonic MPTP mouse model of PD and microarray analysis at 4 days post-MPTP when neurotoxic activity is maximal. Since PD results in gene changes throughout the brain, we assessed MPTP's effects in multiple regions: frontal cortex, striatum and midbrain. Experiment Overall Design: Mus musculus adults were randomly assigned to either MPTP or saline treatment groups. Brain regions of interest (frontal cortex, striatum and midbrain) were dissected from both groups for RNA extraction and hybridization on Affymetrix microarrays.
实验种类:: transcription profiling by array
样本量:: 18
实验设计:
: 无设计数据
数据号:: E-GEOD-7707, GSE7707
数据状态:: 无法自动分析，您可以尝试手动分析数据。

实验库数据相关信息