| GeneLibs

题目:: Transcription profiling of human Ewing sarcoma samples and EWS-FLI-1 inhibited Ewing sarcoma cell lines
ID:
状态:: 发布时间June 15, 2008 , 更新时间 May 2, 2014 , 提交时间 Feb. 12, 2007,
物种:: Homo sapiens
摘要:: The cellular origin of Ewing tumor (ET), a tumor of bone or soft tissues characterized by specific fusions between EWS and ETS genes, is highly debated. Through gene expression analysis comparing ETs with a variety of normal tissues, we show that the profiles of different EWS-FLI1-silenced Ewing cell lines converge toward that of mesenchymal stem cells (MSC). Moreover, upon EWS-FLI1 silencing, two different Ewing cell lines can differentiate along the adipogenic lineage when incubated in appropriate differentiation cocktails. In addition, Ewing cells can also differentiate along the osteogenic lineage upon long-term inhibition of EWS-FLI1. These in silico and experimental data strongly suggest that the inhibition of EWS-FLI1 may allow Ewing cells to recover the phenotype of their MSC progenitor. Experiment Overall Design: Ewing tumors and EWS-FLI-1 inhibited cell lines were profiled on Affymetrix U133A (GPL96) arrays.
实验种类:: transcription profiling by array
样本量:: 39
实验设计:
: 无设计数据
数据号:: E-GEOD-7007, GSE7007
数据状态:: 无法自动分析，您可以尝试手动分析数据。

实验库数据相关信息