Molecular analysis of gastric cancer identifies discrete subtypes associated with distinct clinical characteristics and survival outcomes: the ACRG (Asian Cancer Research Group) study [gastric tumors]

·发布 2015年4月17日 ·更新 2015年4月27日

300

样本数

300

实验数

芯片平台

实验描述

Gastric cancer, a leading cause of cancer related deaths, is a heterogeneous disease, with little consensus on molecular subclasses and their clinical relevance. We describe four molecular subtypes linked with distinct patterns of molecular alterations, disease progression and prognosis viz. a) Microsatellite Instable: hypermutated intestinal subtype tumors occurring in antrum, best overall prognosis, lower frequency of recurrence (22%), with liver metastasis in 23% of recurred cases b) Mesenchymal-like: diffuse tumors with worst prognosis, a tendency to occur at an earlier age and highest recurrence (63%) with peritoneal seeding in 64% of recurred cases, low frequency of molecular alterations c) TP53-inactive with TP53 loss, presence of focal amplifications and chromosomal instability d) TP53-active marked by EBV infection and PIK3CA mutations. The key molecular mechanisms and associated survival patterns are validated in multiple independent cohorts, to provide a consistent and unified framework for further preclinical and clinical research. ACRG Gastric cohort: microarray profiles from 300 gastric tumors from gastric cancer patients.

芯片平台

A-AFFY-44

Affymetrix GeneChip Human Genome U133 Plus 2.0 [HG-U133_Plus_2]（300 例）

样本属性

organism

Homo sapiens

organism part

Gastric tumor

patient

1, 101, 105, 106, 107, 108, 109, 11, 112, 113, 114, 115, 116, 117, 118, 12, 121, 124, 128, 129, 132, 133, 134, 135, 136, 137, 138, 139, 14, 140, 141, 142, 143, 144, 145, 146, 148, 150, 151, 152, 154, 155, 156, 157, 16, 160, 164, 165, 168, 169, 17, 171, 172, 173, 175, 177, 18, 180, 182, 185, 186, 187, 188, 189, 19, 190, 192, 193, 197, 20, 201, 202, 204, 205, 206, 207, 209, 21, 212, 213, 22, 225, 226, 227, 228, 23, 235, 236, 237, 238, 24, 240, 241, 244, 246, 25, 253, 255, 256, 26, 263, 268, 269, 270, 275, 28, 282, 287, 288, 29, 299, 3, 30, 301, 31, 311, 318, 319, 32, 321, 322, 323, 324, 325, 326, 327, 328, 329, 33, 330, 331, 333, 336, 337, 338, 339, 34, 341, 343, 346, 35, 355, 36, 361, 363, 369, 372, 374, 375, 376, 377, 38, 385, 388, 39, 394, 395, 396, 397, 399, 4, 401, 402, 405, 41, 413, 414, 415, 416, 419, 42, 420, 421, 422, 423, 424, 425, 426, 427, 428, 430, 431, 432, 433, 437, 438, 440, 441, 442, 443, 444, 445, 446, 447, 448, 45, 450, 451, 455, 456, 457, 459, 460, 465, 469, 47, 470, 471, 476, 477, 480, 482, 483, 485, 488, 489, 49, 493, 50, 501, 502, 503, 505, 51, 510, 514, 516, 517, 518, 519, 52, 520, 522, 523, 524, 525, 528, 529, 53, 532, 533, 534, 538, 54, 540, 541, 542, 544, 547, 55, 550, 551, 553, 554, 556, 557, 559, 56, 560, 561, 566, 57, 571, 58, 584, 586, 588, 589, 592, 595, 596, 60, 603, 61, 62, 63, 64, 68, 75, 77, 78, 79, 80, 81, 82, 83, 84, 85, 86, 87, 88, 89, 9, 90, 91, 93, 94, 95, 96, 97

实验信息

登记号

E-GEOD-62254

GEO 编号

GSE62254

实验类型

transcription profiling by array

物种

Homo sapiens

发布日期

2015年4月17日

更新日期

2015年4月27日

提交者

Joon H Lee、 Michael Nebozhyn、 James Hardwick、 Jake Fu、 Xiang S Ye、 Mark Ayers、 Andrey Loboda、 Jae M Bae、 Jiangang Liu、 Jason G Jin、 Christoph Reinhard、 Tae S Sohn、 Jian Wang、 Won K Kang、 Jeeyun Lee、 Dai Hongyue、 Kyoung-Mee Kim、 Min G Choi、 Razvan Cristescu、 Patrick Tan、 Sung Kim、 Amit Aggarwal、 Lara Gong、 Jason C Ting、 Chen Ronghua、 Shawn Liu、 In-Gu Do、 Seung T Kim、 Yong G Yue、 Swee S Wong、 Se H Park、 Kun Yu

外部链接

ArrayExpress 原始页 NCBI GEO：GSE62254

分析服务

Molecular analysis of gastric cancer identifies discrete subtypes associated with distinct clinical characteristics and survival outcomes: the ACRG (Asian Cancer Research Group) study [gastric tumors]

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