To investigate the mechanisms of liver cancer progression and metastasis, we did expression profiling of human liver cancer and benign tissues. Experiment Overall Design: Total RNA was extracted from human liver cancer at Experiment Overall Design: various stages (T1-1~4, T3-1~6), 2 normal human livers and HuH7 cell line. Genes showed differentially up- or downregulated Experiment Overall Design: by two-fold with respect to the normal human livers Experiment Overall Design: were identified using GeneSpring software version 7.2 (Silicon Experiment Overall Design: Genetics, Agilent Technologies).