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题目:: Trans-acting regulatory variation in Saccharomyces cerevisiae
ID:
状态:: 发布时间June 5, 2010 , 更新时间 March 27, 2012 , 提交时间 Sept. 1, 2003,
物种:: Saccharomyces cerevisiae
摘要:: Natural genetic variation can cause significant differences in gene expression, but little is known about the polymorphisms that affect gene regulation. We analyzed regulatory variation in a cross between laboratory and wild strains of Saccharomyces cerevisiae. Clustering and linkage analysis defined groups of coregulated genes and the loci involved in their regulation. Most expression differences mapped to trans-acting loci. Positional cloning and functional assays showed that polymorphisms in GPA1 and AMN1 affect expression of genes involved in pheromone response and daughter cell separation, respectively. We also asked whether particular classes of genes were more likely to contain trans-regulatory polymorphisms. Notably, transcription factors showed no enrichment, and trans-regulatory variation seems to be broadly dispersed across classes of genes with different molecular functions
实验种类:: unknown experiment type
样本量:: 360
实验设计:
: 无设计数据
数据号:: E-GEOD-617, GSE617
数据状态:: 无法自动分析，您可以尝试手动分析数据。

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