GIST cell cycle dysregulation is required for progression to high-risk disease but not for resistance to kinase inhibitors

·发布 Dec. 25, 2014 ·更新 Jan. 2, 2015

样本数

实验数

实验描述

Background: To understand the transcriptional consequences of a TP53 modulation in the GIST cell context, we treated GIST430 with increasing doses of the MDM2-inhibitor nutlin-3 (racemate). In this study, 3’ end RNA Sequencing (3SEQ) was used to expression profile GIST430 cell lines treated with DMSO and Nutlin-3, 2.5µM or 10µM for 18h. Then the gene expression profiles between these concentrations were compared.

样本属性

cell line

GIST430

organism

Homo sapiens

organism part

Soft Tissue

tissue archive method

Fresh

tissue type

Gastrointestinal stromal tumor

实验信息

登记号

E-GEOD-59841

GEO 编号

GSE59841, SRP044956

实验类型

RNA-seq of coding RNA

物种

Homo sapiens

发布日期

Dec. 25, 2014

更新日期

Jan. 2, 2015

提交者

Xiangquian Guo、 Michael C Heinrich、 Thomas Mühlenberg、 Brian P Rubin、 Jonathan A Fletcher、 Cesar Serrano、 Jerry Call、 Christopher L Corless、 Sebastian Bauer、 Tamas Ordog、 Cristina R Antonescu、 Carol Beadling、 Matt van de Rijn、 Maria Debiec-Rychter、 Andrea R Wallace、 Barbara Dewaele、 Inga-Marie Schaefer、 Xiangqian Guo、 Anette Duensing、 Adrian Marino-Enriquez、 Janice Patteron

外部链接

ArrayExpress 原始页 NCBI GEO：GSE59841, SRP044956

分析服务

GIST cell cycle dysregulation is required for progression to high-risk disease but not for resistance to kinase inhibitors

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