Genomic alterations of 332 malignant lymphoma using BAC array CGH analysis

·发布 2014年4月1日 ·更新 2014年6月3日

664

样本数

332

实验数

芯片平台

实验描述

Clonal heterogeneity in lymphoid malignancies has been recently reported in adult T-Cell lymphoma/leukemia, peripheral T-cell lymphoma, not otherwise specified, and mantle cell lymphoma (MCL). Our analysis was extended to other types of lymphoma including marginal zone lymphoma, follicular lymphoma, and diffuse large B-cell lymphoma (DLBCL). We examined the results of array comparative genomic hybridization analysis for 332 cases to determine if clonal heterogeneity existed in each case. Results showed that frequencies of clonal heterogeneity varied from 25% to 69% among different types of lymphoma. Multivariate analysis indicated that MCL and DLBCL with clonal heterogeneity showed a significantly poorer prognosis. Interestingly, 9p21.3 (CDKN2A/ 2B) loss and 17p13 (TP53, ATP1B2, SAT2, SHBG) loss were common regions among various types of lymphoma with clonal heterogeneity, suggesting at least in part that loss of these genes may play a role in clonal heterogeneity. We analyzed previously untreated 332 cases of lymphoma (comprising 29 cases of mantle cell lymphoma, 117 cases of diffuse large B-cell lymphoma (DLBCL), 79 cases of Follicular lymphoma, 24 cases of Burkitt lymphoma, 31 cases of mucosa-associated lymphoid tissue (MALT) lymphoma, and 51 peripheral T-cell lymphoma, not otherwise specified (PTCL-NOS)).

芯片平台

A-GEOD-18197

ACC human 2K ver6.0.（332 例）

样本属性

dead or alive at the end of follow-up

None, alive, dead

follow up years

None, 0, 0.0794520547945206, 0.0821917808219178, 0.0833333333333333, 0.10958904109589, 0.166666666666667, 0.25, 0.254794, 0.26849315, 0.284931506849315, 0.333333333333333, 0.336986301369863, 0.33972602739726, 0.383561643835616, 0.416666666666667, 0.421917808219178, 0.454794520547945, 0.460273973, 0.493150684931507, 0.5, 0.504109589, 0.526027397260274, 0.583333333333333, 0.594520547945205, 0.627397260273973, 0.666666666666667, 0.723287671232877, 0.745205479452055, 0.75, 0.767123287671233, 0.802739726, 0.819178082191781, 0.833333333333333, 0.857534246575342, 0.873972602739726, 0.916666666666667, 0.917808219178082, 0.964383561643836, 0.96986301369863, 0.983561643835616, 1.03013698630137, 1.03835616438356, 1.04109589041096, 1.05753424657534, 1.08219178082192, 1.08333333333333, 1.12054794520548, 1.16666666666667, 1.16712328767123, 1.17534246575342, 1.25, 1.26027397260274, 1.27397260273973, 1.33333333333333, 1.34246575342466, 1.40821917808219, 1.43013698630137, 1.51506849315069, 1.54794520547945, 1.61095890410959, 1.62465753424658, 1.66849315068493, 1.67945205479452, 1.68767123287671, 1.69315068493151, 1.70958904109589, 1.74246575342466, 1.76164383561644, 1.83333333333333, 1.93150684931507, 1.95342465753425, 1.99178082191781, 10.4931506849315, 10.572602739726, 11.75, 11.8958904109589, 11.9150684931507, 12.6027397260274, 13.9945205479452, 14.25, 14.3095890410959, 16.3287671232877, 2, 2.02191780821918, 2.03013698630137, 2.0986301369863, 2.14794520547945, 2.18904109589041, 2.20547945205479, 2.22191780821918, 2.2383, 2.25, 2.25753424657534, 2.2986301369863, 2.32054794520548, 2.41095890410959, 2.41369863013699, 2.41666666666667, 2.47945205479452, 2.50958904109589, 2.51780821917808, 2.59178082191781, 2.61917808219178, 2.66027397260274, 2.70958904109589, 2.74794520547945, 2.76986301369863, 2.830136986, 2.83333333333333, 2.91666666666667, 2.92328767123288, 2.94520547945205, 2.98904109589041, 3, 3.16164383561644, 3.18356164383562, 3.29041095890411, 3.41666666666667, 3.45753424657534, 3.52876712328767, 3.58333333333333, 3.63013698630137, 3.66666666666667, 3.71780821917808, 3.72054794520548, 3.75, 3.84109589041096, 4.03561643835616, 4.04657534246575, 4.08333333333333, 4.15890410958904, 4.16666666666667, 4.18356164383562, 4.205479452, 4.24383561643836, 4.24931506849315, 4.25, 4.31506849315068, 4.36164383561644, 4.40821917808219, 4.44109589041096, 4.51506849315069, 4.57534246575342, 4.57808219178082, 4.83333333333333, 5.142465753, 5.14520547945205, 5.16164383561644, 5.18356164383562, 5.19178082191781, 5.265753425, 5.34794520547945, 5.36438356164384, 5.5, 5.56164383561644, 5.75, 5.95068493150685, 6, 6.03835616438356, 6.25479452054795, 6.29041095890411, 6.293150685, 6.31232876712329, 6.4, 6.44657534246575, 6.4958904109589, 6.59178082191781, 6.66666666666667, 6.71506849315069, 6.82191780821918, 6.83333333333333, 6.84109589, 6.91666666666667, 7.07671232876712, 7.13150684931507, 7.25, 7.33333333333333, 7.36164383561644, 7.44383561643836, 7.569863014, 7.75890410958904, 7.96164383561644, 8.04109589041096, 8.21095890410959, 8.31780821917808, 8.65479452054795, 8.72876712328767, 9, 9.40821917808219, 9.41666666666667, 9.47671232876712, 9.83561643835616

genomic loss for 17p13.1 tp53 locus

None, 0, loss

genomic loss/deletion for 9p21.3 cdkn2a locus

None, 0, loss / deletion

international prognostic index

None, high / high intermediate, low / low intermediate

organism

Homo sapiens

sex

None, male

total number of genomic aberrations

None, 0, 1, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 2, 20, 21, 22, 23, 25, 26, 28, 29, 3, 38, 4, 5, 6, 7, 8, 9

with or without clonal heterogeneity

None, clonal heterogeneity (+), clonal heterogeneity (-), NA

实验信息

登记号

E-GEOD-54303

GEO 编号

GSE54303

实验类型

comparative genomic hybridization by array

物种

Homo sapiens

发布日期

2014年4月1日

更新日期

2014年6月3日

提交者

Miyuki Katayama、 Hiroyuki Tagawa、 Masao Nakagawa、 Miyuki Suguro、 Ichiro Takeuchi、 Masao Seto、 Sivasundaram Karnan、 Noriko Fukuhara

外部链接

ArrayExpress 原始页 NCBI GEO：GSE54303

分析服务

Genomic alterations of 332 malignant lymphoma using BAC array CGH analysis

联系地址

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