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题目:: Genetic reconstruction of a functional transcriptional regulatory network
ID:
状态:: 发布时间July 2, 2010 , 更新时间 March 27, 2012 , 提交时间 April 10, 2006,
物种:: Saccharomyces cerevisiae
摘要:: Although global analyses of transcription factor binding provide one view of potential transcriptional regulatory networks, regulation also occurs at levels distinct from transcription factor binding. Here, we use a genetic approach to identify targets of transcription factors in yeast and reconstruct a functional regulatory network. First, we profiled transcriptional responses in S. cerevisiae strains with individual deletions of 263 transcription factors. Then we used directed-weighted graph modeling and regulatory epistasis analysis to identify indirect regulatory relationships between these transcription factors, and from this we reconstructed a functional transcriptional regulatory network. The enrichment of promoter motifs and Gene Ontology annotations provide insight into the biological functions of the transcription factors. Data values are X scores and corresponding p-values derived using an error model. We profiled transcriptional responses upon the individual deletion of more than 260 TFs. We used a directed-weighted graph modelling approach and regulatory epistasis analysis to identify indirect regulatory relationships, and thus constructed a refined, functional transcriptional regulatory network.
实验种类:: unknown experiment type
样本量:: 538
实验设计:
: 无设计数据
数据号:: E-GEOD-4654, GSE4654
数据状态:: 无法自动分析，您可以尝试手动分析数据。

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