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题目:: Transcription profiling of MDR2 knockout mice vs heterozygotes sampled at multiple time points in the early stages of liver carcinogenesis to identify the molecular mechanisms of HCC initiation and promotion
ID:
状态:: 发布时间Nov. 23, 2007 , 更新时间 March 27, 2012 , 提交时间 April 5, 2006,
物种:: Mus musculus
摘要:: We studied the molecular mechanisms of hepatocellular carcinoma (HCC) initiation and promotion using the Mdr2-knockout (Mdr2-KO) mice at pre-cancerous stages of liver disease. These mice lack the liver-specific P-glycoprotein responsible for phosphatidylcholine transport across the canalicular membrane. Portal inflammation ensues at an early age followed by the development of HCC between the ages of 12 and 15 months. Liver tissue samples of Mdr2-KO and control Mdr2-heterozygotes mice aged 3 and 12 months, were subjected to histological, biochemical and gene expression profiling analysis using Affymetrix Mouse Genome Array. The RNA samples from Mdr2-KO and control heterozygous mice aged 3 and 12M (3 males in each experimental group) were subjected to genome scale gene expression profiling with Affymetrix Mouse Array. The gene expression values were extracted with the help of MAS 5.0 software, and analyzed by cluster analysis, and by fold change filtering
实验种类:: transcription profiling by array
样本量:: 12
实验设计:
: 无设计数据
数据号:: E-GEOD-4612, GDS1990, GSE4612
数据状态:: 无法自动分析，您可以尝试手动分析数据。

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