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题目:: Comparison of Bleo, Asthma, TH2 and Infection Models
ID:
状态:: 发布时间Dec. 30, 2006 , 更新时间 May 3, 2014 , 提交时间 Feb. 11, 2006,
物种:: Mus musculus
摘要:: Disease-Specific Gene Expression Profiling in Multiple Models of Lung Disease We profiled lung gene expression in 12 mouse models of infection, allergy, and lung injury. A total of 24 transcripts, including many involved in inflammation and immune activation, were differentially expressed in a substantial majority (9 or more) of the models. Expression patterns distinguished three groups of models: (1) bacterial infection (n = 5), with changes in 89 transcripts, including many related to nuclear factor-B signaling, cytokines, chemokines, and their receptors; (2) bleomycin-induced diseases (n = 2), with changes in 53 transcripts, including many related to matrix remodeling and Wnt signaling; and (3) T helper cell type 2 (allergic) inflammation (n = 5), with changes in 26 transcripts, including many encoding epithelial secreted molecules, ion channels, and transporters. 2 color design with a reference pool
实验种类:: transcription profiling by array
样本量:: 184
实验设计:
: 无设计数据
数据号:: E-GEOD-4231, GSE4231
数据状态:: 无法自动分析，您可以尝试手动分析数据。

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