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题目:: Tenosynovial giant-cell tumor and pigmented villonodular synovitis
ID:
状态:: 发布时间Feb. 24, 2006 , 更新时间 Oct. 18, 2011 , 提交时间 Feb. 2, 2006,
物种:: Homo sapiens
摘要:: Tenosynovial giant-cell tumor (TGCT) and pigmented villonodular synovitis (PVNS) are related conditions with features of both reactive inflammatory disorders and clonal neoplastic proliferations. Chromosomal translocations involving chromosome 1p13 have been reported in both TGCT and PVNS. We confirm that translocations involving 1p13 are present in a majority of cases of TGCT and PVNS and show that CSF1 is the gene at the chromosome 1p13 breakpoint. In some cases of both TGCT and PVNS, CSF1 is fused to COL6A3 (2q35). The CSF1 translocations result in overexpression of CSF1. In cases of TGCT and PVNS carrying this translocation, it is present in a minority of the intratumoral cells, leading to CSF1 expression only in these cells, whereas the majority of cells express CSF1R but not CSF1, suggesting a tumor-landscaping effect with aberrant CSF1 expression in the neoplastic cells, leading to the abnormal accumulation of nonneoplastic cells that form a tumorous mass. Set of arrays organized by shared biological context, such as organism, tumors types, processes, etc. Computed
实验种类:: unknown experiment type
样本量:: 52
实验设计:
: 无设计数据
数据号:: E-GEOD-4166, GSE4166
数据状态:: 无法自动分析，您可以尝试手动分析数据。

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