| GeneLibs

题目:: Regulation of signaling genes by TGFbeta during entry into dauer diapause in C. elegans
ID:
状态:: 发布时间Feb. 2, 2006 , 更新时间 Oct. 18, 2011 , 提交时间 Feb. 2, 2006,
物种:: Caenorhabditis elegans
摘要:: BACKGROUND: When resources are scant, C. elegans larvae arrest as long-lived dauers under the control of insulin/IGF- and TGFbeta-related signaling pathways. : We have identified genes that show different levels of expression in a comparison of wild-type L2 or L3 larvae (non-dauer) to TGFbeta mutants at similar developmental stages undergoing dauer formation. Many insulin/IGF pathway and other known dauer regulatory genes have changes in expression that suggest strong positive feedback by the TGFbeta pathway. In addition, many insulin-like ligand and novel genes with similarity to the extracellular domain of insulin/IGF receptors have altered expression. We have identified a large group of regulated genes with putative binding sites for the FOXO transcription factor, DAF-16. Genes with DAF-16 sites upstream of the transcription start site tend to be upregulated, whereas genes with DAF-16 sites downstream of the coding region tend to be downregulated. Finally, we also see strong regulation of many novel hedgehog- and patched-related genes, hormone biosynthetic genes, cell cycle genes, and other regulatory genes. Set of arrays organized by shared biological context, such as organism, tumors types, processes, etc. Computed
实验种类:: unknown experiment type
样本量:: 20
实验设计:
: 无设计数据
数据号:: E-GEOD-4164, GSE4164
数据状态:: 无法自动分析，您可以尝试手动分析数据。

实验库数据相关信息

DataTable pData

联系方式

微信公众号

实验库 数据相关信息

DataTable pData

联系方式

微信公众号

实验库数据相关信息