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题目:: DNA copy number changes in prostate cancer cell lines
ID:
状态:: 发布时间Jan. 11, 2006 , 更新时间 Oct. 18, 2011 , 提交时间 Jan. 11, 2006,
物种:: Homo sapiens
摘要:: Abstract: BACKGROUND: The aim of this study was to characterize gene expression and DNA copy number profiles in androgen sensitive (AS) and androgen insensitive (AI) prostate cancer cell lines on a genome-wide scale. METHODS: Gene expression profiles and DNA copy number changes were examined using DNA microarrays in eight commonly used prostate cancer cell lines. Chromosomal regions with DNA copy number changes were identified using cluster along chromosome (CLAC). RESULTS: There were discrete differences in gene expression patterns between AS and AI cells that were not limited to androgen-responsive genes. AI cells displayed more DNA copy number changes, especially amplifications, than AS cells. The gene expression profiles of cell lines showed limited similarities to prostate tumors harvested at surgery. CONCLUSIONS: AS and AI cell lines are different in their transcriptional programs and degree of DNA copy number alterations. This dataset provides a context for the use of prostate cancer cell lines as models for clinical cancers. Set of arrays organized by shared biological context, such as organism, tumors types, processes, etc. Computed
实验种类:: unknown experiment type
样本量:: 16
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数据号:: E-GEOD-4017, GSE4017
数据状态:: 无法自动分析，您可以尝试手动分析数据。

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