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题目:: Aging time course
ID:
状态:: 发布时间Jan. 10, 2006 , 更新时间 March 27, 2012 , 提交时间 Jan. 10, 2006,
物种:: Caenorhabditis elegans
摘要:: Transcriptional Profile of Aging in C. elegans Whole-genome analysis of gene expression during chronological aging of the worm provides a rich database of age-specific changes in gene expression and represents one way to distinguish among these models. Using a rigorous statistical model with multiple replicates, we find that a relatively small number of genes (only 164) show statistically significant changes in transcript levels as aging occurs (<1% of the genome). Expression of heat shock proteins decreases, while expression of certain transposases increases in older worms, and these findings are consistent with a higher mortality risk due to a failure in homeostenosis and destabilization of the genome in older animals. Finally, a specific subset of genes is coordinately altered both during chronological aging and in the transition from the reproductive form to the dauer, demonstrating a mechanistic overlap in aging between these two processes. Groups of assays that are related as part of a time series. Age: Age of organism Computed
实验种类:: unknown experiment type
样本量:: 52
实验设计:
: 无设计数据
数据号:: E-GEOD-4005, GSE4005
数据状态:: 无法自动分析，您可以尝试手动分析数据。

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