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题目:: Lineage-specific gene duplication and loss in human and great ape evolution
ID:
状态:: 发布时间Jan. 5, 2006 , 更新时间 Oct. 18, 2011 , 提交时间 Jan. 5, 2006,
物种:: Homo sapiens
摘要:: Given that gene duplication is a major driving force of evolutionary change and the key mechanism underlying the emergence of new genes and biological processes, this study sought to use a novel genome-wide approach to identify genes that have undergone lineage-specific duplications or contractions among several hominoid lineages. Interspecies cDNA array-based comparative genomic hybridization was used to individually compare copy number variation for 39,711 cDNAs, representing 29,619 human genes, across five hominoid species, including human. We identified 1,005 genes, either as isolated genes or in clusters positionally biased toward rearrangement-prone genomic regions, that produced relative hybridization signals unique to one or more of the hominoid lineages. Measured as a function of the evolutionary age of each lineage, genes showing copy number expansions were most pronounced in human (134) and include a number of genes thought to be involved in the structure and function of the brain. This work represents, to our knowledge, the first genome-wide gene-based survey of gene duplication across hominoid species. The genes identified here likely represent a significant majority of the major gene copy number changes that have occurred over the past 15 million years of human and great ape evolution and are likely to underlie some of the key phenotypic characteristics that distinguish these species. A species experiment design type assays differences between distinct species. Using regression correlation, arrayCGH, acCGH
实验种类:: unknown experiment type
样本量:: 36
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数据号:: E-GEOD-3980, GSE3980
数据状态:: 无法自动分析，您可以尝试手动分析数据。

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