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题目:: Transcription profiling of human prognostic samples from neuroblastoma patients for classification of neuroblastoma by integrating gene expression pattern with regional alterations in DNA copy number
ID:
状态:: 发布时间June 12, 2008 , 更新时间 March 27, 2012 , 提交时间 Jan. 3, 2006,
物种:: Homo sapiens
摘要:: The specific genes that influence neuroblastoma biology and are targeted by genomic alterations remain largely unknown. We quantified mRNA expression in a highly annotated series of 101 prospectively collected diagnostic neuroblastoma primary tumors and the expression profiles were determined using Affymetrix U95Av2 arrays. Comparisons between the sample groups allow the identification of genes with localized expression patterns. This study demonstrates that the genomic data can be used to subcategorize the disease into molecular subsets and the regional copy number alterations are correlated with a broad number of transcriptional alterations genome wide. This data also suggests that multiple genes from several discrete regions of the human genome co-operate to supress neuroblastoma tumorigenesis and progression. Experiment Overall Design: A highly annotated series of 101 prospectively collected diagnostic neuroblastoma primary tumors were selected to quantify mRNA expression using an oligonucleotide based microarray. Genomic copy number status at the prognostically relevant loci 1p36,2p24(MYCN), 11q23 and 17q23 was determined by PCR and was aberrant in 26, 20, 40 and 38 cases, respectively. Fetal brain RNA was used as a control sample.
实验种类:: transcription profiling by array
样本量:: 102
实验设计:
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数据号:: E-GEOD-3960, GSE3960
数据状态:: 无法自动分析，您可以尝试手动分析数据。

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