E-GEOD-39084
GSE39084
transcription profiling by array
Homo sapiens
Sporadic early-onset colorectal carcinoma is a distinct clinicopathological and molecular entity
·发布 2014年8月4日
·更新 2014年8月9日
70
样本数
70
实验数
1
芯片平台
1
相关文献
实验描述
Sporadic early onset colorectal carcinoma (EOCRC) is a growing problem that remains poorly understood. Clinical specificities and mechanisms of tumorigenesis might be relevant to both diagnosis and treatment. In this prospective study, clinicopathological features, genomic and gene expression profiles of sporadic EOCRC were compared to other well defined groups of CRC. Seventy selected patients were divided into 4 groups according to age (< 45 or > 60 years) and mismatch repair status. Mutations of key genes involved in colorectal carcinogenesis (P53, KRAS, BRAF, PIK3CA) were detected and the methylator phenotype (CIMP) established. Gene expression profiles (GEP) were obtained using pangenomic Affymetrix GeneChip.
参考文献
芯片平台
A-AFFY-44
Affymetrix GeneChip Human Genome U133 Plus 2.0 [HG-U133_Plus_2]（70 例）
样本属性
age.year
24.9, 29.6, 30.2, 31.7, 33.5, 34.5, 34.7, 35.4, 36.4, 36.9, 37.5, 38.2, 38.8, 38.9, 39.2, 40.2, 40.5, 40.7, 40.8, 41.9, 42.6, 43.5, 44.9, 45, 45.2, 60.8, 60.9, 61.5, 61.8, 62.9, 63, 64.6, 65.8, 66.1, 66.3, 66.4, 66.6, 66.7, 67.3, 67.5, 67.8, 68, 68.1, 70.7, 71, 71.3, 71.4, 71.5, 72, 72.5, 74.5, 74.8, 75.3, 76.4, 76.9, 77.2, 77.8, 78.2, 79.3, 80.9, 81.8, 83.1, 85.6, 86.8, 89.4, 92.4
braf.gene.mutation.status
M, WT
cimp.status
+, -, NA
death
0, 1
death.cause
NA, Tumor
group
MSI.Old, MSI.Young, MSS.Old, MSS.Young
histology
primary colorectal carcinoma
kras.gene.mutation.status
M, WT
lastnews or death.date
2001-03-19, 2001-10-22, 2002-01-07, 2002-04-17, 2002-05-23, 2002-08-10, 2002-10-23, 2002-11-01, 2003-06-01, 2004-01-16, 2004-04-15, 2004-07-31, 2004-10-13, 2004-11-29, 2005-02-28, 2005-04-04, 2005-05-02, 2005-07-21, 2005-11-08, 2005-11-15, 2005-11-30, 2006-01-02, 2006-01-24, 2006-05-10, 2006-07-12, 2006-08-04, 2006-08-28, 2006-10-15, 2006-10-21, 2007-02-23, 2007-02-27, 2007-06-15, 2007-06-18, 2007-06-26, 2007-07-24, 2007-09-11, 2008-01-24, 2008-02-28, 2008-03-04, 2008-03-06, 2008-03-08, 2008-05-05, 2008-07-24, 2008-07-29, 2008-08-05, 2008-08-28, 2008-10-09, 2008-10-16, 2008-10-21, 2008-10-23, 2008-11-10, 2008-11-14, 2008-12-01, 2008-12-29, 2009-01-12, 2009-01-13, 2009-01-14, 2009-01-20, 2009-01-26, 2009-02-02, 2009-02-13, 2009-02-16, 2009-02-19, 2009-02-23, 2009-03-08
lynch.syndrom
0, 1
msi.status mismatch repair status
High, Low, No
organism
Homo sapiens
organism part
colorectal
pik3ca.gene.mutation.status
M, WT
relapse
0, 1, NA
relapse.date
1999-05-06, 1999-09-22, 2000-05-31, 2001-01-10, 2001-01-18, 2001-07-22, 2001-10-01, 2002-01-01, 2002-07-05, 2002-08-07, 2002-08-22, 2002-10-23, 2002-12-18, 2003-01-01, 2003-01-07, 2003-06-10, 2003-07-10, 2004-02-15, 2004-05-01, 2004-10-13, 2005-06-01, 2005-06-07, 2005-08-15, 2006-07-15, 2006-10-25, 2007-07-15, 2008-02-12, NA
relapse.local
0, 1, NA
relapse.local.date
2001-07-22, 2002-01-01, 2002-07-05, 2005-08-15, 2006-07-15, 2008-02-12, NA
relapse.metastasis
0, 1, NA
relapse.metastasis.date
1999-05-06, 1999-09-22, 2000-05-31, 2001-01-10, 2001-01-18, 2001-10-01, 2002-08-07, 2002-10-23, 2002-12-18, 2003-01-01, 2003-01-07, 2003-06-10, 2004-02-15, 2004-05-01, 2004-06-18, 2004-09-06, 2004-10-13, 2005-06-01, 2005-06-07, 2006-07-15, NA
sex
female, male
surgery.date
1999-05-06, 1999-09-16, 1999-09-21, 1999-09-22, 1999-11-08, 1999-11-22, 1999-11-29, 1999-11-30, 1999-12-02, 2000-01-10, 2000-02-29, 2000-05-31, 2000-08-22, 2001-01-17, 2001-01-31, 2001-02-01, 2001-03-02, 2001-04-03, 2001-05-18, 2001-05-22, 2001-05-23, 2001-06-12, 2001-06-27, 2001-06-28, 2001-06-29, 2001-07-19, 2001-08-28, 2001-09-24, 2001-10-01, 2002-01-07, 2002-01-10, 2002-02-01, 2002-02-06, 2002-02-28, 2002-03-01, 2002-06-12, 2002-07-03, 2002-07-22, 2002-07-24, 2002-09-05, 2002-10-09, 2002-10-31, 2002-11-28, 2002-12-18, 2003-01-16, 2003-03-06, 2003-04-16, 2003-05-09, 2003-05-26, 2004-01-29, 2004-02-25, 2004-03-02, 2004-03-09, 2004-05-10, 2004-06-11, 2004-10-13, 2004-11-16, 2005-01-03, 2005-03-25, 2005-04-18, 2005-06-03, 2005-06-07, 2005-06-15, 2005-09-27, 2005-09-30, 2005-10-03, 2005-11-16, 2005-12-08, 2005-12-29
tnm
T0N0M0, T1N0M0, T2N0M0, T2N1M0, T2N1M1, T2N2M0, T3N0M0, T3N0M1, T3N1M0, T3N1M1, T3N2M0, T3N2M1, T4N0M0, T4N1M0, T4N1M1, T4N2M0, T4N2M1
tnm.stage
0, 1, 2, 3, 4
tp53.gene.mutation.status
M, WT
tumor.location
left colon, low rectum, multiple location, right colon
实验信息
登记号
E-GEOD-39084
GEO 编号
GSE39084
实验类型
transcription profiling by array
物种
Homo sapiens
发布日期
2014年8月4日
更新日期
2014年8月9日
提交者
D Bonnet、
L Marisa、
P Cordelier、
G Portier、
Nabila Elarouci、
B Pradère、
J Selves、
P Brousset、
F Meggetto、
MP Gaub、
A De Reynies、
S Kirzin、
R Guimbaud
分析服务
联系地址
山东省济南市章丘区文博路2号
齐鲁师范学院 genelibs生信实验室
山东省济南市高新区舜华路750号
大学科技园北区F座4单元2楼
电话： 0531-88819269
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