Transcription profiling of wild type and H1c, H1d, H1e triple null mouse embryonic stem cells to study the effects of loss of the three linker histone subtypes on gene regulation
Affymetrix expression profiling of wild-type and H1c, H1d, H1e triple null mouse embryonic stem cells revealed that loss of three linker histone subtypes (H1c, H1d and H1e) results in specific changes in gene regulation. Experiment Overall Design: Affymetrix experiments performed on RNA extracted from wild-type and two H1c/H1d/H1e triple null ES cell lines and data acquired in duplicate.