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题目:: Transcription profiling of human lung cancers to identify signatures that reflect the activation status of oncogenic pathways
ID:
状态:: 发布时间June 12, 2008 , 更新时间 March 27, 2012 , 提交时间 Aug. 16, 2005,
物种:: Homo sapiens
摘要:: Signatures of Oncogenic Pathway Deregulation in Human Cancers. The ability to define cancer subtypes, recurrence of disease, and response to specific therapies using DNA microarray-based gene expression signatures has been demonstrated in multiple studies. Such data is also of substantial importance to the analysis of cellular signaling pathways central to the oncogenic process. With this focus, we have developed a series of gene expression signatures that reliably reflect the activation status of several oncogenic pathways. When evaluated in several large collections of human cancers, these gene expression signatures identify patterns of pathway deregulation in tumors, and clinically relevant associations with disease outcomes. Combining signature-based predictions across several pathways identifies coordinated patterns of pathway deregulation that distinguish between specific cancers and tumor sub-types. Clustering tumors based on pathway signatures further defines prognosis in respective patient subsets, demonstrating that patterns of oncogenic pathway deregulation underlie the development of the oncogenic phenotype and reflect the biology and outcome of specific cancers. Furthermore, predictions of pathway deregulation in cancer cell lines are shown to coincide with sensitivity to therapeutic agents that target components of the pathway, underscoring the potential for such pathway prediction to guide the use of targeted therapeutics. Experiment Overall Design: RNA was extracted from frozen tissue of primary lung tumors for gene array analysis.
实验种类:: transcription profiling by array
样本量:: 111
实验设计:
: 无设计数据
数据号:: E-GEOD-3141, GSE3141
数据状态:: 无法自动分析，您可以尝试手动分析数据。

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