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题目:: mgrA acts as a repressor of the rlrA pathogenicity islet
ID:
状态:: 发布时间Aug. 11, 2005 , 更新时间 Oct. 18, 2011 , 提交时间 Aug. 9, 2005,
物种:: Streptococcus pneumoniae
摘要:: Streptococcus pneumoniae normally resides in the human nasopharynx in a non-disease state. In response to yet unknown triggers it can descend to the lower respiratory tract and/or invade the bloodstream. Regulation and activation of virulence genes play essential roles in this process of disease development. A putative transcriptional regulator in S. pneumoniae, MgrA, with homology to a virulence gene activator, mga, of Group A streptococcus (GAS) was previously identified as being required for development of pneumonia in a murine model. In this work we confirm that mgrA is required for both nasopharyngeal carriage and pneumonia. Transcriptional profiling by microarray technology through the growth course of a strain that bears a deletion of mgrA (AC1500) with that of a strain that over expresses Mgra (AC1481) is used to show that MgrA . This is manifested phenotypically by a decrease in adherence to epithelial cells in tissue culture since rlrA pathogenicity islet contains genes mediating adherence. Set of arrays organized by shared biological context, such as organism, tumors types, processes, etc. Computed
实验种类:: unknown experiment type
样本量:: 32
实验设计:
: 无设计数据
数据号:: E-GEOD-3107, GSE3107
数据状态:: 无法自动分析，您可以尝试手动分析数据。

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