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题目:: Gene expression analysis of the colon with and without DNA methyltransferase 1 (Dnmt1) inhibition
ID:
状态:: 发布时间April 14, 2011 , 更新时间 April 26, 2011
物种:: Mus musculus
摘要:: We performed gene expression microarray to assess the effects of reduced DNA methylation on global gene expression. Gene expression profiles of colonic mucosa from mice with two different genotypes (Dnmt1LO/LO and Dnmt1LO/LO, TgVillacIGY) were compared. Dnmt1 expression is repressed only in the Dnmt1LO/LO, TgVillacIGY mice. Total RNA was isolated from the colonic mucosa of four mouse, two biological replicates of each genotype in two technical relicates. Their gene expression profiles were obtained using the Illumina Ref-8 whole-genome expression BeadChip (MouseRef-8 v2.0). We processed our data using the Lumi Id and ReMOAT annotation data base (MouseWG-6 corresponding to GPL6887).
实验种类:: transcription profiling by array
样本量:: 8
实验设计:
: 无设计数据
数据号:: E-GEOD-28386, GSE28386
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