The Genetic Basis of Hypodiploid Acute Lymphoblastic Leukemia

·发布 2013年1月15日 ·更新 2014年6月2日

118

样本数

118

实验数

芯片平台

实验描述

The genetic basis of hypodiploid acute lymphoblastic leukemia (ALL), characterized by aneuploidy and poor outcome, is unknown. Here, using complementary genome-wide profiling approaches, we show that hypodiploid ALL comprises two major subtypes that differ in the severity of aneuploidy, transcriptional profile and submicroscopic genetic alterations. Near haploid cases with 24-31 chromosomes frequently harbor alterations targeting receptor tyrosine kinase- and Ras signaling (71%) and IKZF3 (AIOLOS; 13%). In contrast, low hypodiploid ALL cases with 32-39 chromosomes are characterized by TP53 alterations (88%), almost half of which are present in non-tumor cells, and have alterations of IKZF2 (HELIOS; 53%) and RB1 (41%). Both near haploid and low hypodiploid tumors exhibit activation of Ras and PI3K signaling pathways, and are sensitive to PI3K inhibition, indicating that these drugs should be explored as a new therapeutic strategy for this frequently lethal form of leukemia. Gene expression profiling was performed on 117 single diagnosis tumor samples and one relapse sample [SJHYPO117]. No control or reference samples were included.

芯片平台

A-GEOD-13158

[HT_HG-U133_Plus_PM] Affymetrix HT HG-U133+ PM Array Plate（118 例）

样本属性

all subtype

B-lineage ALL with BCR-ABL1 rearrangement, B-lineage ALL with CRLF2 rearrangement, B-lineage ALL with ETV6-RUNX1 rearrangement, B-lineage ALL with high hyperdiploid karyotype, B-lineage ALL with MLL rearrangement, B-lineage ALL with TCF3-PBX1 rearrangement, High hypodiploid karyotype, Low hypodiploid karyotype, Masked low hypodiploid karyotype, Masked near haploid karyotype, Near diploid karyotype, Near haploid karyotype

Organism

Homo sapiens

实验信息

登记号

E-GEOD-27237

GEO 编号

GSE27237

实验类型

transcription profiling by array

物种

Homo sapiens

发布日期

2013年1月15日

更新日期

2014年6月2日

提交者

Gordana Raca、 Shann-Ching Chen、 Michael J Borowitz、 Mark Minden、 Ernesto Diaz-Flores、 Susan L Heatley、 Jared Becksfort、 Cheng Cheng、 Linda Holmfeldt、 Charles G Mullighan、 Geoffrey Neale、 John Easton、 Stephen P Hunger、 Richard K Wilson、 Deqing Pei、 Andrew J Carroll、 Gang Wu、 Matthew Parker、 Lucinda L Fulton、 Sharyn Baker、 Sheila A Shurtleff、 Michelle Churchman、 Wendy Stock、 Meenakshi Devidas、 Julie M Gastier-Foster、 Elaine R Mardis、 Raul C Ribeiro、 Mignon L Loh、 Susana C Raimondi、 Li Ding、 L B To、 Guangchun Song、 Ross A Dickins、 Xiang Chen、 Kelly McCastlain、 Michael Rusch、 James R Downing、 Robert S Fulton、 Jinghui Zhang、 Letha A Phillips、 Hans G Drexler、 Kristy Boggs、 Nyla A Heerema、 Erin Hedlund、 Christina Drenberg、 Debbie Payne-Turner、 Paula Marlton、 David J Dooling、 Linda Holmfeldt、 Brent Wood、 Kerri Ochoa、 Anna Andersson、 Ian D Lewis、 Samir N Patel、 Jing Ma、 Ching-Hon Pui、 Lei Wei

外部链接

ArrayExpress 原始页 NCBI GEO：GSE27237

分析服务

The Genetic Basis of Hypodiploid Acute Lymphoblastic Leukemia

联系地址

微信公众号