| GeneLibs

题目:: The effects of EBV transformation on gene expression
ID:
状态:: 发布时间March 1, 2011
物种:: Homo sapiens
摘要:: Epstein-Barr virus (EBV)-transformed lymphoblastoid cell lines (LCLs) provide a conveniently accessible and renewable resource for functional studies in humans. The ability to accumulate multidimensional data pertaining to the same individual cell lines, from complete genomic sequences to detailed gene regulatory profiles, further enhances the utility of LCLs as a model system. A lingering concern, however, is that the changes associated with EBV transformation of LCLs reduce the usefulness of LCLs as a surrogate model for primary tissues. To evaluate the validity of this concern, we compared global gene expression profiles between CD20+ primary B cells and CD3+ primary T cells sampled from six individuals. Six independent replicates of transformed LCLs were derived from each sample. The study included 96 RNA samples: 8 different types (B cell + T cell + 6 independent LCLs per individual) x 6 individuals x 2 technical replicates (each RNA sample hybridized in duplicate).
实验种类:: transcription profiling by array
样本量:: 96
实验设计:
: 无设计数据
数据号:: E-GEOD-26210, GSE26210
数据状态:: 无法自动分析，您可以尝试手动分析数据。

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