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题目:: Transcription profiling of rat FGFR3-K650E mutant and wild type PC12 cells
ID:
状态:: 发布时间Oct. 8, 2007 , 更新时间 March 27, 2012 , 提交时间 May 3, 2005,
物种:: Rattus norvegicus
摘要:: To investigate signaling pathways activated by FGFR3 mutations through an analysis of altered expression of downstream transcriptional targets, we performed gene expression profiling of stably transfected inducible PC12 cells expressing a chimeric receptor (PFR3) consisting of the extracellular domain of human platelet derived growth factor receptor (PDGFR) and the transmembrane and intracellular domains of human FGFR3 under the control of the zinc inducible metalliothionein promoter. Cells expressing the wildtype receptor (i.e. zinc induced) were compared to cells expressing the mutant receptor PFR3K650E, which contains the thanatophoric dysplasia type II mutation, K650E. See PubMed ID for further description of samples.
实验种类:: transcription profiling by array
样本量:: 8
实验设计:
: 无设计数据
数据号:: E-GEOD-2606, GSE2606, GDS1234
数据状态:: 无法自动分析，您可以尝试手动分析数据。

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