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题目:: Comparative analysis of hESCs and iPSCs-derived hepatocyte-like cells reveals current drawbacks and possible strategies for improved differentiation
ID:
状态:: 发布时间Jan. 20, 2011 , 更新时间 March 27, 2012
物种:: Homo sapiens
摘要:: Two independent protocols for deriving HLCs from hESCs and iPSCs were adopted and further characterization included immunocytochemistry, real-time RT-PCR, and in vitro functional assays. Comparative microarray-based gene expression profiling was conducted on these cells and compared to the transcriptomes of human fetal liver and adult liver progenitors. HLCs derived from hESCs and hiPSCs showed significant functional similarities, similar expression of genes important for liver physiology and common pathways. However, specific differences between the two cell types could be observed. Total RNA obtained from undifferentiated hESCs, iPSCs, HLCs (hepatocyte-like cells)-derived from hESCs and iPSCs, fetal forskin fibroblasts and fetal liver.
实验种类:: transcription profiling by array
样本量:: 32
实验设计:
: 无设计数据
数据号:: E-GEOD-25744, GSE25744
数据状态:: 无法自动分析，您可以尝试手动分析数据。

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