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题目:: Progressive lengthening of 3' untranslated regions of mRNAs by alternative polyadenylation during mouse embryonic development
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状态:: 发布时间Aug. 31, 2010 , 更新时间 March 27, 2012
物种:: Mus musculus
摘要:: The 3' untranslated regions (3' UTRs) of mRNAs contain cis-acting elements for posttranscriptional regulation of gene expression. Here, we report that mouse genes tend to express mRNAs with longer 3' UTRs as embryonic development progresses. This global regulation is controlled by alternative polyadenylation and coordinates with initiation of organogenesis and aspects of embryonic development, including morphogenesis, differentiation, and proliferation. Using myogenesis of C2C12 myoblast cells as a model, we recapitulated this process in vitro and found that 3' UTR lengthening is likely caused by weakening of mRNA polyadenylation activity. Because alternative 3' UTR sequences are typically longer and have higher AU content than constitutive ones, our results suggest that lengthening of 3' UTR can significantly augment posttranscriptional control of gene expression during embryonic development, such as microRNA-mediated regulation. Two biological replicates of C2C12 growth and differentiation conditions, repesctively
实验种类:: transcription profiling by array
样本量:: 4
实验设计:
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数据号:: E-GEOD-23871, GSE23871
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