Genome wide transcriptional profiling of c-Cbl deficient hematopoietic stem and progenitor cells
ID:
状态:
发布时间Aug. 12, 2010
, 更新时间 June 10, 2011
物种:
Mus musculus
摘要:
Expression of genes that are differentially expressed between c-Cbl control and c-Cbl mutant hematopoietic stem and progenitor cells were identified through this approach. Interestingly, several leukemia associated genes, particularly transcription factors, were differentially expressed between c-Cbl WT and c-Cbl mutant hematopoietic stem and progenitor cells. Hematopoietic stem and progenitor cells of c-Cbl control and c-Cbl mutant mice were sorted based on their defined immunophenotype. Gene expression studies were performed using Illumina microarray chips.