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题目:: Global transcriptomic profiling of ischemic/reperfusion injury in an in vivo wild-type mouse model
ID:
状态:: 发布时间Jan. 10, 2011 , 更新时间 June 26, 2012
物种:: Mus musculus
摘要:: Ischemic stroke triggers severe focal hypoperfusion accompanied with deprivation of oxygen and glucose to the cerebral tissue, together with loss of ATP, depolorization of neurons, elevated extracellular potassium concentration, and subsequently leads to excitotoxicity as well as increased oxidative stress promoting microvascular injury, blood-brain-barrier deregulation, post-ischemic inflammation and eventually the consequential neurological deficit. Although reperfusion of ischemic brain tissue is critical for restoring normal function, it can paradoxically result in secondary damage, called ischemia/reperfusion (I/R) injury. Microarray analysis was performed on the right striatum and cortex (corresponded to infarct area) of post-I/R injured brain tissues of wild-type (WT-MCAO) using Illumina mouse Ref8 V2 genechips. Suture-induced middle cerebral artery occlusion was induced for 2h followed by reperfusion, with tissue extraction taking place 2h, 8h and 24h post-reperfusion (n=4 respectively). Sham controls were included in this study too (n=4 respectively).
实验种类:: transcription profiling by array
样本量:: 32
实验设计:
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数据号:: E-GEOD-23160, GSE23160
数据状态:: 无法自动分析，您可以尝试手动分析数据。

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