Feedback amplication of fibrosis through matrix stiffening and COX-2 suppression
ID:
状态:
发布时间July 15, 2010
, 更新时间 March 27, 2012
物种:
Homo sapiens
摘要:
We tested the hypothesis that increasing matrix stiffness on which normal human lung fibroblasts are grown promotes the expression of a fibrogenic cellular transcriptomic program. Keywords: Human lung fibroblast, matrix stiffness, PTGS2, COX-2, Prostaglandin E2 Total RNA extracted from normal human lung fibroblasts from 3 human subjects and separately grown on 5 discrete matrix stiffness conditions: 100, 400, 1600, 6400, 25600 Pascals.