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题目:: Copy number data from GIST with KIT mutation
ID:
状态:: 发布时间Aug. 27, 2010 , 更新时间 March 27, 2012
物种:: Homo sapiens
摘要:: In addition to KIT and PDGFRA mutations, sequential accumulation of other genetic events is involved in the development and progression of gastrointestinal stromal tumors (GISTs). Until recently, the significance of these other alterations has not been thoroughly investigated. The combination of gene expression profiling and high-resolution genomic copy number analysis offers a detailed molecular portrait of GISTs, providing an essential comprehensive knowledge necessary to guide the discovery of novel target genes involved in tumor development and progression. Fresh tissue specimens from 25 patients with GIST were collected and high-resolution genomic copy number analyses were performed using Affymetrix SNP array 6.0. GIST tumor samples from mutated (KIT or PDGFRA) or Wild Type patients were labeled for hybridization on Affymetrix microarrays. Copy number analysis of Affymetrix SNP6.0 arrays was performed for 25 GIST samples, then compared to gene expression data.
实验种类:: comparative genomic hybridization by array
样本量:: 25
实验设计:
: 无设计数据
数据号:: E-GEOD-20709, GSE20709
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