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题目:: Gene Expression in Human Lung Type II Cells
ID:
状态:: 发布时间Dec. 30, 2009 , 更新时间 May 2, 2014
物种:: Homo sapiens
摘要:: Normal lung function relies on mature function of alveolar type II cels, which have numerous functions including to regulate ion and fluid flux, produce immune molecules, and synthesize and secrete surfactant to stabilize air spaces. Differentiation of type II cells from precursor epithelial cells is accelerated by exposure of cultured cells to glucocorticoid and cAMP. In these studies we used DNA microarray analysis to identify genes of both fetal and adult type II cells that are regulated by glucocorticoid plus cAMP. In the first series of experiments we isolated epithelial cells from fetal human lung and cultured cells for 5 days with or without hormone treatment (dexamethasone plus 8-Br-cAMP plus isobutylmethylxanthine, DCI) and then performed DNA microarray analysis. In the second series of experiments, we isolated type II cells from adult human postmortem lung and cultured cells for 5 days with or without DCI and performed DNA microarray analysis.
实验种类:: transcription profiling by array
样本量:: 25
实验设计:
: 无设计数据
数据号:: E-GEOD-19699, GSE19699
数据状态:: 无法自动分析，您可以尝试手动分析数据。

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