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题目:: Gene expression timecourse in zebrafish whole eye in response to optic nerve crush
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状态:: 发布时间Feb. 21, 2010 , 更新时间 May 1, 2014 , 提交时间 Dec. 3, 2009,
物种:: Danio rerio
摘要:: It is well-established that neurons in the adult mammalian central nervous system are terminally differentiated and, if injured, will be unable to regenerate their connections. In contrast to mammals, zebrafish and other teleosts display a robust neuroregenerative response. Following optic nerve crush (ONX), retinal ganglion cells (RGC) regrow their axons to synapse with topographically correct targets in the optic tectum, such that vision is restored in ~21 days. What accounts for these differences between teleostean and mammalian responses to neural injury is not fully understood. A time course analysis of global gene expression patterns in the zebrafish eye after optic nerve crush can help to elucidate cellular and molecular mechanisms that contribute to a successful neuroregeneration. We used microarrays to detail the global gene expression patterns underlying a successful regeneration or the optic nerve following injury. Experiment Overall Design: Microarray analysis was performed on total RNA extracted from whole eye following optic nerve crush (ONX) or sham surgery at defined intervals (4, 12, & 21 days).
实验种类:: transcription profiling by array
样本量:: 12
实验设计:
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数据号:: E-GEOD-19298, GSE19298
数据状态:: 无法自动分析，您可以尝试手动分析数据。

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