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题目:: Overexpression of Hoxd4 transcription factor alters transcriptional profiles in mouse chondrocytes at E18.5
ID:
状态:: 发布时间Oct. 15, 2010 , 更新时间 June 10, 2011 , 提交时间 Nov. 12, 2009,
物种:: Mus musculus
摘要:: Homeobox genes of the Hox class are required for proper patterning of skeletal elements and play a role in cartilage differentiation. In transgenic mice with overexpression of Hoxd4 during cartilage development, we observed severe defects, namely physical instability of cartilage, accumulation of immature chondrocytes, and decreased maturation to hypertrophy. To define the molecular basis underlying these defects, we performed gene expression profiling using the Affymetrix microarray platform. Embryos were dissected from four different mouse litters at E18.5. Embryos from each litter were grouped according their genotype: TA=control; TR=transgenic.
实验种类:: transcription profiling by array
样本量:: 8
实验设计:
: 无设计数据
数据号:: E-GEOD-18991, GSE18991
数据状态:: 无法自动分析，您可以尝试手动分析数据。

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