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题目:: Microarray studies of drb0090/drb0091 double mutant vs wild type
ID:
状态:: 发布时间May 6, 2010 , 更新时间 May 2, 2014 , 提交时间 Aug. 18, 2009,
物种:: Deinococcus radiodurans R1
摘要:: Deinococcus radiodurans exposed to higher doses of gamma radiation showed induced levels of DRB0091 polypeptide annotated as a putative response regulator in an operon expressing downstream to DRB0090, histidine kinase. Deletion of drB0090 generated double mutation for both of these genes, which showed decreased tolerance to DNA damage and impairment in DSB repair. Recombinant DR0090 protein showed phosphotransferase activity on its cognate response regulator, DRB0091. The drb0090 deletion mutant was checked for its role in regulation of gene expression in response to DNA damage in Deinococcus radiodurans R1. The gene expression profiling of this mutant was carried out by complete transcriptome analysis of these cells grown under normal as well as upon gamma-irradiated conditions and compared with wild type cells. DRB0090/DRB0091 mutant showed extreme sensitivity to gamma radiation and was used for Gene expression profiling using microarray and compared with wild type data. All the genes subjected to microarray analysis are as described in the genome sequence of bacterium available at
实验种类:: transcription profiling by array
样本量:: 4
实验设计:
: 无设计数据
数据号:: E-GEOD-17720, GSE17720
数据状态:: 无法自动分析，您可以尝试手动分析数据。

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