实验描述
Gene expression profiles of normal human mammary tissue from BRCA1 mutation carriers, non-BRCA1/2 mutation carriers and normal women. RNA was prepared from normal breast tissue (confirmed by pathology) from reduction mammoplasties (n=5) and prophylactic mastectomies of known BRCA1 (n=7) and non-BRCA1/2 mutation carriers (n=8). non-BRCA1/2 carriers were individuals with a strong family history of breast cancer (kConFab Category 1 (
参考文献
Aberrant luminal progenitors as the candidate target population for basal tumor development in BRCA1 mutation carriers.
Lim E, Vaillant F, Wu D, Forrest NC, Pal B, Hart AH, Asselin-Labat ML, Gyorki DE, Ward T, Partanen A, Feleppa F, Huschtscha LI, Thorne HJ, kConFab, Fox SB, Yan M, French JD, Brown MA, Smyth GK, Visvader JE, Lindeman GJ
芯片平台
A-MEXP-1173
Illumina HumanWG-6 v3.0 Expression BeadChip(20 例)
样本属性
beadchip barcode
4380071008, 4380071010, 4380071031, 4632486019, 4634617009, 4634617015, 4634617027
beadchip section
A, B, C, D, E, F
hybridization date
10-31-08, 2-18-09
mutation
BRCA1, non-BRCA1/2 mutation, Normal
tissue
Preneoplastic breast tissue