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题目:: Domestication causes large-scale effects on gene expression in rainbow trout: Analysis of the brain transcriptome
ID:
状态:: 发布时间May 16, 2010 , 更新时间 May 2, 2014 , 提交时间 June 28, 2009,
物种:: Oncorhynchus mykiss
摘要:: Domestication has produced faster-growing strains of animals for use in agriculture, but selection has been applied with little knowledge of the underlying genetic changes that arose throughout the process. Mammals and birds have been domesticated for thousands of years whereas fish have been domesticated only recently; therefore, wild progenitor strains remain for comparison. Rainbow trout (Oncorhynchus mykiss) have undergone intensive selection and domesticated strains grow more rapidly than extant wild strains. To assess physiological pathways altered by domestication, whole-genome mRNA expression was measured in brain, muscle and liver of size-matched domestic and wild trout using a 16K (cGRASP) salmonid microarray. A large number of genes differed between strains, ranging from 3% of genes in brain to 9% in muscle. Domestic fish had more down-regulated genes in the brain relative to wild fish, whereas more genes were up-regulated in domestic liver and muscle. Relative to wild fish, there was a down-regulation of cell division and an up-regulation of structural genes in the brain of domestic fish. In liver from domestic fish, there was an up-regulation of genes related to transport with a down-regulation of lipid binding. Analysis of the functional categories for muscle indicated that most pathways, including pathways related to metabolism and catabolism, were up-regulated in domestic fish. Comparison of these results to other genomic studies on transgenic, domestic and wild salmonids suggests that similar physiological pathways are altered systemically to support faster rates of growth, regardless of the underlying genetic alteration that has caused the altered growth. Microarray analyses were performed on nine individual fish per group of wild type and domestic rainbow trout hybridized (one slide per individual) against a common wild-type RNA pool.
实验种类:: transcription profiling by array
样本量:: 36
实验设计:
: 无设计数据
数据号:: E-GEOD-16889, GSE16889
数据状态:: 无法自动分析，您可以尝试手动分析数据。

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