Transcription profiling of mouse overexpressing APPSw mice vs. controls
ID:
状态:
发布时间June 11, 2008
, 更新时间 June 10, 2011
, 提交时间 July 9, 2004,
物种:
Mus musculus
摘要:
Gene expression changes in mice overexpressing amyloid precursor protein with the Swedish mutation (Tg2576; APPSw). The gene expression levels in male 12 month-old APPSw mice (GSM26708, GSM26709) were compared to those in male nontransgenic littermate control mice (GSM26706, GSM26707). Data were analyzed with MAS 5.0 and scaled to 2500. See Stein, TD, Anders, NJ, DeCarli, C, Chan, SL, Mattson, MP, and Johnson JA. Neutralization of transthyretin reverses the neuroprotective effects of secreted APP in APPSw mice resulting in tau phosphorylation and loss of hippocampal neurons: support for the amyloid hypothesis. J Neurosci. in press.