Transcription profiling of human colon cells (CCD-18Co) exposed to an orange extract rich in flavanones
ID:
状态:
发布时间March 28, 2009
, 更新时间 June 10, 2011
, 提交时间 March 20, 2009,
物种:
Homo sapiens
摘要:
We used microarrays to investigate gene expression changes in human colon normal fibroblasts exposed to a bitter orange extract enriched in flavanones (and previously subjected to in vitro gastro-duodenal digestion) to determine possible modulatory beneficial effects induced by these plant-derived compounds on the colon cells. Experiment Overall Design: We used ~90% confluent monolayers of colon CCD-18Co cells exposed to either small doses of pre-digested extract from bitter orange containing a mixture of flavanones (Treated) or equivalent quantities of digestive enzymes and salts (Control). Treatments were done in triplicate.