Transcription profiling of neurons or astrocytes treated with grape seed extract
ID:
状态:
发布时间April 18, 2009
, 更新时间 June 10, 2011
, 提交时间 March 18, 2009,
物种:
Rattus norvegicus
摘要:
We examined the effect of grape seed extract (GSE), which are known to protect neurons against oxidative stress, on primary cultures of hippocampal astrocytes. GSE increased interleukin-6 (IL-6) expression. Microarrays are used to examine the effects of GSE on primary cultures of hippocampal neurons and astrocytes. Experiment Overall Design: Primary cultures of hippocampal neurons were treated with 0, 1, or 10 ug/ml of GSE for 24 hrs. Primary cultures of hippocampal astrocytes were treated with 0, 1, 10, or 100 ug/ml of GSE for 24 hrs.