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题目:: Gene expression profiles of HEK293 cells following induction of wild-type and mutated FOXP3
ID:
状态:: 发布时间May 15, 2010 , 更新时间 March 27, 2012 , 提交时间 Dec. 2, 2008,
物种:: Homo sapiens
摘要:: The forkhead DNA-binding protein FOXP3 is critical for the development and suppressive function of CD4+CD25+ regulatory T cells (TREG), which play a key role in maintaining self tolerance. Functionally, FOXP3 is capable of repressing transcription of cytokine genes regulated by the Nuclear Factor of Activated T cells (NFAT). Various mechanisms have been proposed by which FOXP3 mediates these effects. Using novel HEK cell lines that inducibly express either wild-type (WT) or mutant FOXP3, we have identified genome-wide expression patterns showing among other features that NFAT2 as an early target of FOXP3-mediated transcriptional repression. Six biological replicates of wild-type induced FOXP3 cell lines and six biological replicates of mutated FOXP3 cell line were studied.
实验种类:: transcription profiling by array
样本量:: 12
实验设计:
: 无设计数据
数据号:: E-GEOD-13798, GSE13798
数据状态:: 无法自动分析，您可以尝试手动分析数据。

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